Martha Elise Lambert Stokely, MS PhD

Professor of Neurological Sciences


Alisa Chebotarova, MD PhD

Previous Positions

  • Assistant Professor of Neuroscience, Xavier School of Medicine, Aruba and American University of the Caribbean, St. Maarten
  • Assistant Professor of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth,, Texas

Contact Information

Office: 1(246)6222454 | email: This email address is being protected from spambots. You need JavaScript enabled to view it.

  • Biography

    Dr. Stokely brings with her a noble philosophy that says “Medical students are a sacred responsibility.” Beginning her medical career with a degree in Chemistry from the University of Texas at Arlington, Dr. Stokely went on to acquire her Ph.D. from the University of North Texas Health Science Center. Her employment history began with Postdoctoral Associate, Department of Pharmacology and Neuroscience in 2003. Dr. Stokely ultimately became an Associate Professor of Neuroscience, in 2013 and then came to teach at AUIS in 2016.

    Dr. Stokely says that her focus is on using learning style assessment tools to improve a student’s success during the basic science years of medical school. She also holds two patents, one being the application of “Combinational therapies to protect, regenerate, and repair both axons and myelin in neurodegenerative-inflammatory conditions of the nervous system.” Her honors include being invited to speak at the 2005 Interdisciplinary Symposium on Women in Science.

    DR. STOKELY ANSWERS YOUR QUESTIONS:

    1. Why did you choose your specialty? I fell in love with Neuroscience because it's beautiful, intricate, and elegant of function.

    2. Why did you choose your particular area of biomedical research? Research is one way we can help to make the world a better place. I select my research projects in my best attempt to match my assets and abilities with projects where believe I can do the most genuine good.

    3. Why Did You Decide to Become a Medical School Teacher? Helping to make better doctors is the slow-but-sure way to make the world a better place, one patient at a time. It's not the most glamorous way, but it works.

    4. What are your strengths as a teacher in the medical school? I pay attention and listen carefully to each of my students, so I can understand how best to bridge the gap between their current understanding of the nervous system and the understanding they will need to have as a physician (or possibly a neurologist). I also work very hard to streamline all my teaching materials so they're easy to learn from and are readily accessible for students from all learning styles. My students are important. They're the reason I go to work in the morning.

    5. What do you want to achieve as a teacher at AUIS? I want to make the world a better place, one doctor at a time. And I hope that each of those doctors to make the world a better place, one patient at a time. We all pay-forward.

    6. What do you like to do in your spare time and why? I like to sail, to read, & to appreciate the natural world around me.

  • Research Interests

    Dr. Stokely’s current educational research interests focus on using learning style assessment tools to improve students' success during the basic science years of medical school.

    Her laboratory research interests have always involved mechanisms affecting the balance of degenerative/regenerative processes in the central nervous system, and how these processes may be modulated to oppose neurological disease.

  • Presentations

    2013 - NO-dependent pathway of the adaptation to ischemic damage of lower limb tissue under an experimental injection of mesenchymal stem cells. Second mini symposium "Stem cell day". Kyiv. Uk

    2014 - Dynamics of changes in a content of free nitric oxide metabolites in kidney tissue in the transient acute renal ischemia under experimental conditions. All-Ukrainian scientific and practical conference with international participation "Aspects of pharmaceutical and medical research at the present stage", Lugansk, Uk

    2016 - Content of adenyl nucleotides in a culture of rat mesenchymal stem cells. International scientific conference of the young scientists in medicine, Kursk-Voronezh-Kazan, Russia

  • Publications

    Stokely M. E., P. Garg, M. A. Bhat and P. Koulen J Neurosci Res. (2008) 86(9):2111-24. PMID: 18335521 Transient 5-(4-phenylbutoxy)psoralen (PAP-1) treatment dissociates developing pathologies in autoimmune optic neuritis into two distinct pathology profiles. https://www.ncbi.nlm.nih.gov/pubmed/18335521

    Stokely M. E. and E. L. Orr. J Neurotrauma, (2008) 25(1):52-61. PMID: 18355158 Acute Effects of Calvarial Damage on Dural Mast Cells, Pial Blood Vessels, and Cerebral Cortical Histamine Levels in Rats and Mice. https://www.ncbi.nlm.nih.gov/pubmed/18355158

    Stokely M. E., M. A. Bhat, and P. Koulen. J. Neurosci. Methods (2007) 166(2):217-228. PMID: 17719649 Microfluorimetry defines early axonal damage in a rat model of optic neuritis: A novel method targeting early CNS autoimmunity. https://www.ncbi.nlm.nih.gov/pubmed/17719649

    Stokely M. E., S-Y Hwang, J-Y Hwang, B. Fan, M. A. King, K. Inokuchi, Y. Cai, S. Somlo, and P. Koulen. J Neurosci Res. (2006) 84(8):1727-1737. PMID: 17016857 Polycystin-1 can interact with Homer 1/Vesl-1 in postnatal hippocampal neurons. https://www.ncbi.nlm.nih.gov/pubmed/17016857

    Stokely M. E., T. Yorio, and M. A. King J Neurosci Res. (2005) 79(5):598-607. PMID: 15678512 Endothelin-1 modulates anterograde fast axonal transport in the central nervous system. https://www.ncbi.nlm.nih.gov/pubmed/15678512

    Stokely M. E., S. T. Brady, and T. Yorio Invest Ophthalmol Vis Sci (2002) 43:3223-3230. PMID: 12356828 Effects of endothelin-1 on components of anterograde axonal transport in optic nerve. https://www.ncbi.nlm.nih.gov/pubmed/12356828

    Stokely, M. E. and T. Yorio Abstract: American Society for Neurochemistry 2000 J Neurochem 74:S29. Intravitreal Endothelin-1 increases newly synthesized proteins axonally transported into rat optic nerve at 4 hours post-administration. Stokely, M. E. and T. Yorio Abstract: Association for Research in Vision and Ophthalmology 2000.Invest Ophthalmol Vis Sci 41:S896 Intravitreal Endothelin-1 Significantly Alters the Entry of Newly Synthesized Protein into Rat Optic Nerve.

    Hulet C. J, R. R. Krishnamoorthy, M. E. Stokely, T. Yorio, and G. Prasanna, Abstract: Association for Research in Vision and Ophthalmology 2001 Invest Ophthalmol Vis Sci 2001;42:S191. Effect of endothelin-1 on expression of nitric oxide synthase-2 and endothelin receptors in the retina of brown norway rats: A pilot study.

    Stokely, M. E. and T. Yorio Abstract: Association for Research in Vision and Ophthalmology 2001 Invest Ophthalmol Vis Sci 42:S829. Intravitreal Endothelin-1 Significantly Alters Fast Axonal Transport Characteristics In Rat Optic Nerve.

    Stokely, M. E. and T. Yorio Abstract: International Society for Neurochemistry/ American Society for Neurochemistry 2001 J Neurochem 78:41. Intravitreal Endothelin-1 Significantly Alters The Temporal Characteristics And The Protein Profiles Of Anterograde Fast Axonal Transport In Rat Optic Nerve

    Stokely M. E., S. T. Brady, and T. Yorio Abstract # 132: Univ. North Texas Health Science Ctr., Research Appreciation Day 2002 Effects of intravitreal endothelin-1 on anterograde fast axonal transport are cargo-selective, in rat optic nerve.

    Stokely, M. E. and T. Yorio Abstract #614: Association for Research in Vision and Ophthalmology 2002 Intravitreal endothelin-1 significantly decreases slow axonal transport in rat optic nerve.

    Stokely M. E., S. T. Brady, and T. Yorio Abstract: American Society for Neurochemistry 2002 J Neurochem 81:(Suppl. 1)94 Endothelin-B receptor mediates effect of intravitreal endothelin on mitochondria-associated anterograde axonal transport.

    Stokely M. E., S. T. Brady, and T. Yorio Abstract: American Society for Neurochemistry 2003 J Neurochem 2003 85:(Suppl.1)48 Isoflurane anesthesia alters anterograde fast axonal transport in both normal and in ETB-glaucoma-model rat optic nerves

    Stokely M. E., U. Dell, F. J. Ollivier, W. W. Dawson, D. E. Brooks, M. E. Kallberg, T. Yorio, A. M. Komaromy Abstract: Society for Neuroscience 2003 Program No. 263.1. 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. Online. Non-anesthetic effects of isoflurane alter neurophysiologic function in the optic nerve.

    Stokely M. E. and M. A. King Abstract # 10017: American Society for Neurochemistry 2004 A marker for lipid rafts may transport in the fast component of anterograde axonal transport in hippocampal slices

    Stokely M. E. and M. A. King Abstract control number # 498: Society for Neuroscience 2004 A marker for lipid rafts moves at rates consistent with the fast component of anterograde axonal transport in hippocampal slices

    Stokely M. E Abstract # 10030: American Society for Neurochemistry 2006 Histochemical assays to determine functionality of optic nerve in a MOG-induced model of optic neuritis

    Stokely M. E Abstract # 10030: American Society for Neurochemistry 2006 Histochemical assays to determine functionality of optic nerve in a MOG-induced model of optic neuritis

    P. Garg, P. Koulen and M. E. Stokely Abstract # 10349/PTW03-02: American Society for Neurochemistry Conference 2008 Differential responses of inducible heat shock protein 72 to treatments in an early model of autoimmune optic neuritis.

    Peterson-Ford A.M. and M.E. Stokely Abstract: Society for Neuroscience 2008 Dose-response effect of glucose-oxygen deprivation on fast axonal transport of synaptic vesicles in hippocampal slices.

    M. G. Spear and M. E. Stokely Abstract: American Society for Neurochemistry Conference 2009 Axonal accumulation of APP may precede dephosphorylation of neurofilaments in autoimmune optic neuritis.

  • Activities

    T. Yorio, G. Prasanna, A. Dibas, and M. E. Stokely "Endothelin Antagonists and Endothelin-Converting Enzyme Inhibitors for the Treatment of Glaucoma," U.S. Patent Application Serial No. 60/285,960.

    M. E. Stokely and P. Koulen “Combinational therapies to protect, regenerate, and repair both axons and myelin in neurodegenerative-inflammatory conditions of the nervous system.” Initiated on April 24, 2008. International Patent Application # PCT/US2009/060198.

    SOCIETY MEMBERSHIPS AND NATIONAL OFFICES: American Society for Neurochemistry (member 1999-present)

    ASN OFFICES & COMMITTEES: Scientific Program Committee for the 2011 National Meeting (2009-2011)

    Nominating Committee of the American Society for Neurochemistry (2010-present)

    Chair Organizing Committee American Society for Neurochemistry’s Educational Event (2010)

    Deputy-Chair Standing Rules Committee of American Society for Neurochemistry (2009-2010)

    Standing Rules Committee of the ASN (2004-2010)

    Society for Neuroscience (member since 1994)

    Association for Research in Vision and Ophthalmology (member glaucoma section since 2000)

    REVIEWER FOR SCIENTIFIC JOURNALS

    Neuroscience

    Histology and Histopathology

    COMPLETED RESEARCH:

    Beginning Grant-In-Aid (Stokely) 07/01/07-06/30/10 $118,182 direct costs American Heart Association/American Stroke Association Axon and synaptic pathology in an ex vivo model of ischemic stroke: Mechanisms and treatments. The major goal of this project is to understand mechanisms that may underlie secondary neuronal losses associated with ischemic stroke by using an ex vivo hippocampal slice model to assess early post-ischemic axon and synaptic pathology, define the role(s) that ApoE isoforms and endothelin-1 play in expansion of the initial infarct, and assay the therapeutic potential of “neuroprotective” ApoE isoforms and phytoestrogens against secondary axon and synaptic pathology following ischemic stroke.

    1 R21 AT003605-01A1 (Stokely) 06/01/07-05/31/10 $275,000 direct costs NIH/NCCAM Mechanisms and effects of phytoestrogen treatment in autoimmune optic neuritis The major goal of this project is to evaluate the effects of phytoestrogen treatment on the inhibition of endothelin-1 synthesis and its role in the development of early multiple sclerosis-like pathologies in the optic nerve, using a very early and highly sensitive animal model for this disease.

    MEMBER - SCIENTIFIC PROGRAM COMMITTEE for ASN 2011, organizing the scientific program for American Society for Neurochemistry’s 42nd Annual Meeting in St. Louis, March 19-23, 2011.

    CHAIR - ORGANIZING COMMITTEE FOR THE AMERICAN SOCIETY FOR NEUROCHEMISTRY’S EDUCATIONAL STUDENT EVENT at the American Society For Neurochemistry’s 41ST Annual Meeting in Santa Fe, New Mexico March 6-10, 2010.

    CHAIR - “NEURODEGENERATION AND NEUROTOXICITY” PRESENTATION SESSION at the American Society For Neurochemistry’s 40th Annual Meeting in Charleston, South Carolina March 7-11, 2009.

    CO-CHAIR “LATE-BREAKING ABSTRACTS” SESSION at the American Society For Neurochemistry’s 37th Annual Meeting in Portland, Oregon (March 15, 2006).

    INVITED SPEAKER WITH PUBLISHED PROCEEDINGS “Women In Neurochemistry,” Interdisciplinary Symposium on Women, Tarleton State University, Stephenville, TX, March 24, 2005. Research Achievement Award 2006, awarded by Alcon Research Ltd., Fort Worth, Texas

    Nominee for 2005 Lighthouse International’s 25th annual Pisart Vision Award, New York, New York, 2005, award ($10,000) for extraordinary contribution to the prevention, cure, or treatment of severe vision impairment or blindness

    Ruth L. Kirschstein National Research Service Award Postdoctoral Fellow (EM Meyer and MA King, mentors) Neurobiology of Aging, Department of Neuroscience, University of Florida at Gainesville, Gainesville, Florida, April 2003-January 2005

    Nominee for 2003 Lewis Rudin Glaucoma Prize of the New York Academy of Medicine, New York, New York, 2003, award ($50,000) for the previous year’s most outstanding article in glaucoma research (for “Effects of endothelin-1 on components of anterograde axonal transport in optic nerve,” by Stokely, et al. published in IOVS 43:3223-3230).

    North Texas Eye Research Institute Travel Grant 2001, from the North Texas Eye Research Institute, Fort Worth, Texas. Joseph M. and Eula C. Lawrence Travel Scholarship Award 2000, from the Retina Research Foundation, Houston, Texas.

  • News

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Education & Training

  • PhD: University of North Texas Health Science Center
  • MS: Texas Christian University
  • BA: University of Texas at Arlington

Departments & Committees

  • Neuroscience
  • Evidence Based Medicine
  • Chair,Student Academic Review Committee
  • Faculty Affairs Committee
  • Drug testing Committee
  • Ethics Committee