Ahmmed Ally, MD PhD

Professor of Physiology and Pharmacology


Alisa Chebotarova, MD PhD

Previous Positions

  • Professor and Chair, Physiology, Saba University
  • Professor of Pharmaceutical Sciences at South College School of Pharmacy, TN and Massachusetts College of Pharmacy and Health Sciences University,
  • Loma Linda University School of Medicine, University of New England College of Medicine

Contact Information

Office: 1(246)6222454 | email: This email address is being protected from spambots. You need JavaScript enabled to view it.

  • Biography

     
  • Research Interests

    The questions being asked in my research are highly relevant to provide a better understanding of the physiological, molecular and biochemical mechanisms involved in the interaction of the cardiovascular and skeletal muscle systems with exercise during stroke and heart failure. Exercise prevents mortality caused by ischemic heart diseases and reduces the incidence of strokes. Furthermore, exercise is considered to play an important role in weight control and stress, both potential risk factors in cardiovascular diseases, including many heart maladies. Exercise is recommended by physicians for the treatment and prevention of hypertension. Thus, further scientific information related to exercise is important for both preventive and curative medicine. One can reasonably understand that identification of the central neural mechanisms that control the cardiovascular responses during exercise will make a major contribution to our understanding of the regulation of these systems. However, much remains to be determined about the molecular, cellular, and neurochemical mechanisms that are related in the integration for adjustment of cardiovascular activity appropriate for the intensity of muscular contraction./p>

    My research will identify such molecular and neurochemical changes within the ventrolateral medulla (VLM) that play a role in cardiovascular regulation during static exercise, and they will determine whether these mechanisms are impaired following ischemic brain injury or stroke. Over 750,000 patients per year experience focal cerebral ischemic insults, and thus understanding mechanisms regulating cardiovascular functions during stroke are crucial for the development of new treatment strategies. Exercise both before and after stroke greatly improves the health of stroke victims, and therefore it is also important to define the mechanisms underlying this condition. Brain ischemia engages a cascade of cellular & biochemical events, including alteration in Calcium homeostasis, glutamate and gamma-amino butyric acid (GABA) release, generation of nitric oxide (NO) via the activation of neuronal (nNOS), endothelial (eNOS) and inducible (iNOS) NO synthase, and ultimately apoptosis. The NOS proteins are both neurotoxic and/or neuroprotective and are likely critical factor(s) during cerebral ischemia. Neurons of rostral (RVLM) and caudal (CVLM) VLM receive direct glutamatergic and GABAergic projections from areas affected during cerebral ischemia. Further, ischemic stroke decreases sympathetic nerve activity and increases c-fos & c-jun mRNAs expression in the VLM. We have shown that cardiovascular responses are attenuated during static muscle contraction following cerebral ischemia. Further, our laboratory has demonstrated that NO in the VLM modulates cardiovascular functions during static exercise by changing the ration of glutamate/GABA release within the RVLM and CVLM. Proposed experiments for the next several years will test the hypothesis that focal cerebral ischemia alters the expression of one or all NOS isoforms and their messenger RNAs, thereby changing neurochemical release/reuptake within the RVLM and CVLM and thus in turn, altering cardiovascular functions during static exercise.

    My research uses an integrated, in vivo approach using simultaneous measurements of cardiovascular variables, and RVLM/CVLM neurotransmitter concentrations, and in vitro messenger RNA analyses with real-time PCR and western blot NOS protein expression analysis. My research will attempt to delineate regulatory mechanisms within the ventrolateral medulla involved in integration of cardiovascular activity during static exercise and determine whether this integration is altered in a diseased state, i.e., ischemic brain injury or stroke.

  • Presentations

    Effects of central application of physostigmine on blood pressure in anesthetized cats. April 1990, Japanese Pharmacological Society Conference, Kyoto, Japan.

    Inhibitory effect by electrical stimulation of the trigeminal nucleus on the Spino-Bulbo-Spinal reflex in cats, and effects of drugs on it. April 1990, Japanese Pharmacological Society Conference, Kyoto, Japan.

    Effects of intravenous physostigmine on blood pressure in anesthetized cats. April 1990, Japanese Pharmacological Society Conference, Kyoto, Japan.

    Central cholinergic mechanism concerning with cardiovascular responses in anesthetized cats. August 1991, Southeast Asian/Western Pacific Pharmacologists Conference, Hong Kong Pharmacological Society, Hong Kong

    Effects of L-DOPA and clonidine on the segmental spinal reflex and Spino-Bulbo-Spinal reflex potentials in anesthetized cats. August 1991, Southeast Asian/Western Pacific Pharmacologists, Hong Kong Pharmacological Society, Hong Kong.

    Effects of L-DOPA and clonidine on the spinal reflex and Spino-Bulbo-Spinal reflex potentials in anesthetized cats.  April 1991, Japanese Pharmacological Society Conference, Sendai, Japan.

    Effect of MK-801 on the convulsion induced by a combination of enoxacin with fenbufen. February 1992, Japanese Pharmacological Society Conference, Tokyo, Japan.

    Effects of intracerebroventricular administration of physostigmine on the exercise pressor reflex in anesthetized cats. April 1993, Experimental Biology 1992 Conference, Anaheim, CA.

    Microdialysis of an opioid agonist into the L7 dorsal horn of anesthetized cats attenuates the exercise pressor reflex. November 1993, Society for Neuroscience Conference, Washington D.C.

    Effects of microdialysis of clonidine into the spinal cord on the exercise pressor reflex in anesthetized cats.  April 1994, Experimental Biology 1994 Conference, Miami, FL.

    Modulation of the reflex arterial pressure response to muscle contraction by 5-HT1 agonists in the dorsal horn of the spinal cord. April 1994, Experimental Biology Conference, Miami, FL.

    Cardiovascular effect elicited by central administration of physostigmine in conscious cats. November 1994, Society for Neuroscience Conference, New Orleans, LA.

    Spinal release of substance P during muscle contraction:  Effect of 5-HT1A receptors activation.  November 1994, Society for Neuroscience Conference, New Orleans, LA.

    Central administration of clonidine attenuates the reflex cardiovascular responses to exercise in conscious cats. August 1995, Medicine and Science in Sports and Exercise Conference, Austin, TX.

    Intracerebroventricular administration of physostigmine attenuates the cardiovascular responses to static exercise in conscious cats. April, 1995, Experimental Biology 1992 Conference, San Francisco, CA.

    Non-NMDA receptor blockade attenuates the pressor response to muscle contraction but not stretch.  August 1995, Medicine and Science in Sports and Exercise Conference, Austin, TX.

    Blockade of NMDA receptors in cat dorsal horn attenuates the pressor response to static muscle contraction and passive stretch.  April 1995, Experimental Biology Conference, San Francisco, CA.

    Central administration of physostigmine evokes pressor response in conscious cats. February 1995, New England Pharmacologists Conference, Burlington, VT.

    Cardiovascular effects elicited by intracerebroventricular administration of clonidine in conscious cats. October 1995, Society for Neuroscience Conference, Atlanta, GA.

    Modulation of the cardiovascular responses to static muscle contraction by blockade of AMPA-Glutamate receptors in the lateral reticular nucleus in anesthetized rats. November 1995, Society for Neuroscience Conference, Atlanta, GA.

    Cardiovascular effects elicited by intravenous administration of clonidine in conscious cats. April 1996, Experimental Biology Conference, New Orleans, LA.

    Modulation of the cardiovascular responses to static muscle contraction by activation of 5-HT1A receptors within the ventrolateral medulla in anesthetized rats.  April 1996, Experimental Biology Conference, New Orleans, LA.

    Cardiovascular response and renal sympathetic nerve activity during static exercise in conscious cats: effect of intraventricular administration of clonidine. March 1996, Brain Research: 16th European Winter Conference, Paris, France.

    Activation of 5-HT1A receptors in the ventrolateral medulla attenuates the pressor response during static muscle contraction.  February 1996, New England Pharmacologists Conference, Braintree, MA.

    Central administration of clonidine evokes a hypotensive response in conscious cats.  February 1996, New England Pharmacologists Conference, Braintree, MA.

    Ventral medullary administration of an opioid agonist modulates the cardiovascular responses during static muscle contraction. November 1996, Society for Neuroscience Conference, Anaheim, CA.

    Glutamate release in the rostral ventrolateral medulla mediates cardiovascular responses during tibial nerve stimulation-evoked muscle contraction. April 1997, Experimental Biology Conference, Los Angeles, CA.

    Differential effects of rostral and caudal ventrolateral medullary AMPA-Glutamate receptor antagonism on cardiovascular responses to tibial nerve stimulation-evoked muscle contraction. April 1997, Experimental Biology Conference, Los Angeles, CA.

    Modulation of pressor response to muscle contraction by CNQX, a non-NMDA antagonist, during ventrolateral medullary administration. April 1997, Japanese Pharmacological Society Conference, Tokyo, Japan.

    Serotonin release in the rostral ventrolateral medulla (rVLM) mediates cardiovascular responses to muscle contraction: Effects of rVLM 5-HT1A receptor activation. April 1997, Experimental Biology Conference, Washington D.C.

    AMPA-Glutamate receptors in rostral and caudal ventrolateral medulla modulates cardiovascular responses during muscle contraction. February 1997, New England Pharmacologists Conference, Providence, RI.

    Glutamate is a neurotransmitter associated with cardiovascular responses during static muscle contraction. February 1997, New England Pharmacologists Conference, Providence, RI.

    Effects of rostral ventrolateral medullary 5-HT1A receptor activation on the exercise pressor reflex and the release of 5-hydroxytryptamine during static muscle contraction. May 1997, ASPET Conference, Las Vegas, NV.

    Serotonin is a neurotransmitter associated with cardiovascular responses during static muscle contraction: Effects of rostral ventrolateral medullary 5-HT1A receptor activation during rest and exercise. February 1997, New England Pharmacologists Conference, Providence, RI.

    Effects of ventrolateral medullary NMDA receptor antagonism on cardiovascular responses during static muscle contraction in anesthetized rats. November 1997, Society for Neuroscience Conference, New Orleans, LA.

    Extracellular norepinephrine and dopamine in the rostral ventrolateral medulla increases during static muscle contraction; Effects of rostral ventrolateral medullary NMDA receptor antagonism. April 1998, Experimental Biology Conference, New Orleans, LA.

    Effects of rostral ventrolateral medullary NMDA receptor antagonism on cardiovascular responses and extracellular serotonin during muscle contraction. April 1998, Experimental Biology Conference, New Orleans, LA.

    Neurochemical characterization of extracellular 5-HT, norepinephrine, and dopamine in the rostral ventrolateral medulla during two forms of noxious stimuli: modulation by NMDA-receptor antagonism. April 1998, Experimental Biology Conference, New Orleans, LA.

    Neurochemical characterization of extracellular 5-HT, norepinephrine, and dopamine in the rostral ventrolateral medulla: modulation by two forms of noxious stimuli. April 1998, Experimental Biology Conference, New Orleans, LA.

    Extracellular serotonin and norepinephrine changes in ventromedial hypothalamus and prefrontal cortex after banana, serotonin, and tryptophan feedings. April 1998, Experimental Biology Conference, New Orleans, LA.

    Extracellular monoamines in the rostral ventrolateral medulla increases during static muscle contraction; Effects of NMDA receptor antagonism. February 1998, New England Pharmacologists Conference, Portland, ME.

    Rostral ventrolateral medullary NMDA receptor antagonism modulates cardiovascular responses during muscle contraction via a change in extracellular 5-HT concentration. February 1998, New England Pharmacologists Conference, Portland, ME.

    NMDA-receptor antagonism modulates extracellular monoamines in the rostral ventrolateral medulla during noxious stimuli. February 1998, New England Pharmacologists Conference, Portland, ME.

    Biogenic amines in the rostral ventrolateral medulla during noxious stimuli. February 1998, New England Pharmacologists Conference, Portland, ME.

    Extracellular monoamines concentrations change in ventromedial hypothalamus and prefrontal cortex after banana, serotonin, and tryptophan feedings. February 1998, New England Pharmacologists Conference, Portland, ME.

    Nitric Oxide in the rostral ventrolateral medulla modulates cardiovascular responses during muscle contraction. November 1998, Society for Neuroscience Conference, San Francisco, CA.

    Effects of nitric oxide into the caudal ventrolateral medulla on cardiovascular responses during muscle contraction. November 1998, Society for Neuroscience Conference, San Francisco, CA.

    NMDA receptor antagonism in the rostral ventrolateral medulla attenuates cardiovascular responses during mechanical but not thermal nociception. November 1998, Society for Neuroscience Conference, San Francisco, CA.

    AMPA-receptor blockade within the rostral ventrolateral medulla modulates cardiovascular responses during mechanical but not thermal nociception. November 1998, Society for Neuroscience Conference, San Francisco, CA.

    Role of nitric oxide in the periaqueductal grey on cardiovascular responses and extracellular glutamate concentrations during mechanical and thermal nociception. April 1999, Experimental Biology Conference, New Orleans, LA.

    Cardiovascular responses during stimulation of peripheral nerves. April 1999, Experimental Biology Conference, New Orleans, LA.

    Simultaneous neuronal release of glutamate occurs in both rostral and caudal ventrolateral medulla during static muscle contraction. April 1999, Experimental Biology Conference, New Orleans, LA.

    Effects of rostral ventrolateral medullary NMDA receptor antagonism on cardiovascular responses and extracellular glutamate during muscle contraction. April 1999, Experimental Biology Conference, New Orleans, LA.

    Does rostral or caudal ventrolateral medullary AMPA-receptor antagonism modulate cardiovascular responses via altering extracellular glutamate levels during muscle contraction? April 1999, Experimental Biology Conference, New Orleans, LA.

    Does rostral ventrolateral medullary 5-HT1A-receptor activation attenuate cardiovascular responses via altering extracellular glutamate levels during muscle contraction? April 1999, Experimental Biology Conference, New Orleans, LA.

    Role of nitric oxide in the RVLM on cardiovascular responses and extracellular glutamate concentrations during mechanical and thermal nociception. April 1999, Experimental Biology Conference, New Orleans, LA.

    Microdialysis of nitric oxide precursor into the periaqueductal grey modulates cardiovascular responses and extracellular glutamate concentrations during mechanical and thermal nociception. February 1999, New England Pharmacologists Conference, Boston, MA.

    Muscle contraction-induced release of glutamate in both rostral and caudal ventrolateral medulla is neuronal in origin. February 1999, New England Pharmacologists Conference, Boston, MA.

    Rostral ventrolateral medullary NMDA-receptor blockade modulates cardiovascular responses and extracellular glutamate levels during muscle contraction. February 1999, New England Pharmacologists Conference, Boston, MA.

    Extracellular glutamate levels and cardiovascular responses during muscle contraction following rostral or caudal ventrolateral medullary AMPA-receptor blockade. February 1999, New England Pharmacologists Conference, Boston, MA.

    Extracellular glutamate levels and cardiovascular responses during muscle contraction following rostral ventrolateral medullary 5-HT1A receptor-activation. February 1999, New England Pharmacologists Conference, Boston, MA.

    Cardiovascular responses during static muscle contraction: modulation by nitric oxide in the RVLM and the CVLM via altering extracellular glutamate levels.  July 11, 1999, FASEB Summer Research Conference, VT.

    Effects on extracellular glutamate concentrations in the RVLM during opioidergic modulation of the exercise pressor reflex.  November 1999, Society for Neuroscience Conference, New Orleans, LA.

    Effects on extracellular glutamate concentrations in the RVLM and the CVLM during nitric oxide modulation of the exercise pressor reflex. November 1999, Society for Neuroscience Conference, New Orleans, LA.

    Role of monoamines in the RVLM and CVLM modulating cardiovascular responses during muscle contraction following AMPA-receptor antagonism. April 2000, Experimental Biology Conference, Los Angeles, CA.

    Role of monoamines in the RVLM modulating cardiovascular responses during muscle contraction following opioid-receptor activation. April 2000, Experimental Biology Conference, Los Angeles, CA.

    Role of monoamines in the RVLM modulating cardiovascular responses during muscle contraction after 5-HT1A receptor activation. April 2000, Experimental Biology Conference, Los Angeles, CA.

    Neurochemicals in the RVLM and CVLM during exercise pressor reflex: modulation following AMPA-receptor antagonism. February 2000, New England Pharmacologists Conference, Braintree, MA.

    Neurochemicals in the RVLM during the exercise pressor reflex: modulation following opioid-receptor activation. February 2000, New England Pharmacologists Conference, Braintree, MA.

    Neurochemicals in the RVLM during the exercise pressor reflex: modulation following 5-HT1A receptor activation. February 2000, New England Pharmacologists Conference, Braintree, MA.

    Cardiovascular responses and GABA release in the RVLM and CVLM during muscle contraction. November 2000, Society for Neuroscience Conference, Miami, FL.

    Nitric oxide mediated modulation of cardiovascular responses via GABA during static muscle contraction.  April 2001, Experimental Biology Conference, New Orleans, LA.

    Developmental changes in ryanodine- and IP3-sensitive Ca2+ pools in the ovine basilar artery. April 2001, Experimental Biology Conference, New Orleans, LA.

    Static muscle contraction induced changes in glutamate and GABA within RVLM and CVLM in intact and barodenervated rats. November, 2001, Society for Neuroscience Conference, San Diego, CA.

    Pressor responses to static muscle contraction and neurotransmitter release in ventrolateral medulla following middle cerebral artery occlusion and reperfusion. April 2002, Experimental Biology Conference, San Diego, CA.

    Attenuations of 5HT-induced contractions by an ERK inhibitor in fetal and adult cerebral arteries. April 2002, Experimental Biology Conference, San Diego, CA.

    Differential cardiovascular responses to blockade of nNOS within the ventrolateral medulla during static muscle contraction. November 2002, Society for Neuroscience Conference, New Orleans, LA.

    Cardiovascular responses and neurotransmitter changes following blockade of eNOS within the ventrolateral medulla during static muscle contraction. April 2003, Experimental Biology Conference, Miami, FL.

    NOS modulation of the exercise pressor reflex via neurotransmission. November 2003, Society for Neuroscience Conference, San Diego, CA.

    Neuronal NOS expression in the ventrolateral medulla in intact versus stroked rats. April 2004, Experimental Biology Conference, Los Angeles, CA.

    Differential cardiovascular responses to blockade of iNOS protein within the ventrolateral medulla during static muscle contraction. November 2004, Society for Neuroscience Conference, Orlando, FL.

    Interaction among the three isoforms of nitric oxide synthase and the exercise pressor reflex. May 2005, Integrative Biology of Exercise Conference: American Physiological Society, Austin, TX.

    Neuronal NOS antagonism within the ventrolateral medulla modulates nNOS expression and cardiovascular functions during static exercise. August 2005, International Union of Physiological Societies and Experimental Biology, Paris, France.

    Endothelial nitric oxide synthase (eNOS) expresses differentially within the ventrolateral medulla in rats following transient middle cerebral artery occlusion and reperfusion.  April 2006, Experimental Biology Conference, New Orleans, LA.

    Abundance of endothelial nitric oxide synthase (eNOS) within the ventrolateral medulla in stroke rats.  February 2007, New England Pharmacologists Conference, Burlington, VT.

    Blockade of neuronal nitric oxide synthase (nNOS) within the periaqueductal gray differentially modulates neurotransmission and cardiovascular responses during mechanical and thermal nociception. April 2007, Experimental Biology Conference, San Diego, CA.

    Effects of endothelial NOS (eNOS) antagonism on eNOS expression within the ventrolateral medulla and cardiovascular responses during static skeletal muscle contraction.  April 2007, Experimental Biology Conference, San Diego, CA.

    Role of neuronal nitric oxide synthase and neurotransmitters within the periaqueductal gray in cardiovascular functions during nociception. February 2007, New England Pharmacologists Conference, Braintree, MA.

    Role of endothelial nitric oxide synthase antagonism on eNOS protein expression within the brainstem that affects cardiovascular activities during static exercise February 2007, New England Pharmacologists Conference, Braintree, MA.

    Cardiovascular responses and neurotransmitter changes during static exercise after blockade of angiotensin receptor-AT1 subtype within the ventrolateral medulla.  November 2007, Society for Neuroscience, San Diego, CA.

    Changes in cardiovascular responses, glutamate and GABA release following blockade of eNOS within the periaqueductal grey during mechanical and thermal nociception. April 2008, Experimental Biology Conference, San Diego, CA,

    Inducible NOS expression within the ventrolateral medulla affecting cardiovascular functions in stroke rats. April 2008, Experimental Biology Conference, San Diego, CA.

    Changes in cardiovascular responses, glutamate and GABA release following blockade of eNOS within the periaqueductal grey during mechanical and thermal nociception. February 2008, New England Pharmacologists Conference, Portland, ME.

    Inducible NOS expression within the ventrolateral medulla affecting cardiovascular functions in stroke rats. February 2008, New England Pharmacologists Conference, Portland, ME.

    Angiotensin receptors within the ventrolateral medulla modulate the exercise pressor reflex. February 2008, New England Pharmacologists Conference, Portland, ME.

    Cardiovascular responses following blockade of iNOS within the periaqueductal grey during mechanical, heat and cold nociception. April 2009, Experimental Biology Conference, New Orleans, LA.

    Blockade of angiotensin II (Type II) receptors within the ventrolateral medulla differentially modulates cardiovascular responses during static exercise. April 2009, Experimental Biology Conference, New Orleans, LA.

    Cardiovascular responses following blockade of iNOS within the periaqueductal grey during mechanical, heat and cold nociception. February 2009, New England Pharmacologists Conference, Burlington, VT.

    Blockade of angiotensin II (Type II) receptors within the ventrolateral medulla differentially modulates cardiovascular responses during static exercise. February 2009, New England Pharmacologists Conference, Burlington, VT.

    Role of inducible nitric oxide synthase (iNOS) antagonism within the ventrolateral medulla on cardiovascular responses and iNOS expression during exercise pressor reflex. April 2010, Experimental Biology Conference, New Orleans, LA.

    Post-treatment with uridine and melatonin following traumatic brain injury reduces edema in various brain regions in rats. November 2011, Society for Neuroscience Conference, Washington, D.C.

    Effects of medullary administration of nitric oxide precursor on cardiovascular responses and neurotransmission during static exercise in stroke rats. April 2012, Experimental Biology Conference, San Diego, CA.

    Cardiovascular responses during static skeletal muscle contraction following neuronal NOS blockade within the ventrolateral medulla in stroke rats. April 2013, Experimental Biology Conference, Boston, MA.

    Inducible nitric oxide synthase (iNOS) blockade within the ventrolateral medulla differentially modulates the Exercise Pressor Reflex in stroke rats. April 2014, Experimental Biology Conference, San Diego, CA

    Role of inducible nitric oxide synthase (iNOS) within the ventrolateral medulla on the Exercise Pressor Reflex in stroke rats. August 7, 2014, 1st Annual Central Valley Symposium on Basic and Clinical Sciences, Clovis, CA.

    Effects of neuronal NOS blockade within the ventrolateral medulla on cardiovascular responses during static skeletal muscle contraction in stroke rats. August 7, 2014, 1st Annual Central Valley Symposium on Basic and Clinical Sciences, Clovis, CA.

    Endothelial nitric oxide synthase (eNOS) blockade within the ventrolateral medulla differentially modulates the Exercise Pressor Reflex in stroked-rats. March 2015, Experimental Biology Conference, Boston, MA

    August, 2014 Ally, A. and T. Maher: 1st Annual “Central Valley Symposium on Basic and Clinical Sciences”; College of Pharmacy, California Health Sciences University, Clovis, CA, USA:
    Title: “Drug Delivery by Microdialysis”

    Series Forum; East Tennessee State University, Bill Gatton College of Pharmacy, Johnson City, TN

    October, 2011 “Regulation of Cardiovascular function following stroke”; Department of Cardiovascular Medicine,

    Kyushu University School of Medicine, Fukuoka, Japan

    October, 2011 “Practicing Medicine is an Art”; Induction to Clinical Rotation” ceremony for 3rd Year Medical

    Students, Dhaka Medical College, Dhaka, Bangladesh

    September, 2011 “Regulation of Cardiovascular function during several types of nociception”; Department of Pharmacology, Chiba University School of Medicine, Inohana, Chiba-shi, Japan

    June, 2005 Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, MA.

    June, 2003 Renal Division, Harvard Institutes of Medicine, Brigham and Women’s Hospital, Boston, MA

    May, 2003 Department of Biology, University of Texas, Brownsville, TX

    May, 2003 Department of Basic Sciences, Touro University School of Osteopathic Medicine, Vallejo, CA

    August, 2002 Department of Pharmacology, Temple University School of Pharmacy, Philadelphia, PA

    May, 2002 Department of Physiology and Pharmacology, Des Moines University College of Osteopathic Medicine and Surgery, Des Moines, Iowa

    March, 2002 Department of Pharmacology, School of Pharmacy, Wyoming University, Laramie, Wyoming

    June, 2000 Department of Pathology, Emory University, Atlanta, Georgia

    May, 2000 Department of Neuroscience, Ramapo College of New Jersey, Mahwah, New Jersey

    March, 2000 Department of Physiology, Youngstown State University, Youngstown, Ohio

    June, 1999 Departments of Pharmacology and Physiology, Chiba University, School of Medicine, Chiba, Japan

    May, 1998 48th Annual Conference, American Heart Association, (Maine, New Hampshire, Vermont Affiliate).

    January, 1997 Department of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas

    April, 1996 46th Annual Conference, American Heart Association, Maine Affiliate.

    January, 1996 Department of Pharmacology, Tokyo University, School of Medicine, Tokyo, Japan.

    December, 1995 Departments of Pharmacology and Physiology, Chiba University, School of Medicine, Chiba, Japan.

    December, 1995 Department of Internal Medicine, Chiba University Medical Hospital, Chiba, Japan.

    August, 1995 Department of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas.

    August, 1994 Animal Resources Center, University of Texas Southwestern Medical Center, Dallas, Texas.

    July 15, 1994 Department of Pharmacology, University of New England, College of Osteopathic Medicine, Biddeford, Maine.

    Sept. 29, 1990 12th Pharmacology Research Meeting for Eastern Japan Association of Pharmacologists, Yamagata, Japan.

    July 10, 1989 Kissei Pharmaceuticals, Nagano, Japan.

     

    Benediction, 2005 Fall Commencement Ceremony, Palm Beach Atlantic University, West Palm Beach, Florida

    Invocation, 2006 Hooding and Awards Ceremony, Lloyd L. Gregory School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, Florida

    Breakfast Prayer: June 14, 2006: Christian Pharmacists Fellowship International (CPFI) Annual Meeting, Myrtle Beach, South Carolina

  • Publications

    DISSERTATION Ally A.: Pharmacological studies of a central cholinergic mechanism concerned with cardiovascular responses in anesthetized cats. Chiba University, School of Medicine, Chuo-ku, Inohana 1-8-1, Chiba 260, Japan. Chiba University Journal, March 1992.

    PEER REVIEWED PUBLISHED ARTICLES Ally A.: Blood pressure responses to intra-hypothalamic injection of carbachol in anesthetized cat. Journal of Bangladesh College of Physicians and Surgeons, 9:53-59, 1991.

    Murayama S., Hara Y., Ally A., Suzuki T., and Tamagawa M.: Central stimulatory effects of a combination of new-quinolone antimicrobials and non-steroidal anti-inflammatory drug in mice. Folia Pharmacologica Japonica, 99:13-18, 1992.

    Hara Y., Ally A., Suzuki T., and Murayama S.: Effects of drugs on the convulsions induced by the combination of a new-quinolone antimicrobial, enoxacin, and a non-steroidal anti-inflammatory drug, fenbufen, in mice. Folia Pharmacological Japonica, 100:301-305, 1992.

    Hara Y., Ally A., and Murayama S.: Central cardiovascular effects of physostigmine in anesthetized cats. Neuropharmacology, 31(9): 923-928, 1992.

    Hara Y., and Ally A.: Effect of morphine on the suppression of spino-bulbo-spinal reflex potentials by conditioning stimuli to the trigeminal nucleus in cats. Journal of Bangladesh College of Physicians and Surgeons, 10(2): 47-50, 1992.

    Ally A., Hara Y., and Murayama S.: Cardiovascular effects of central administration of cholinomimetics in anesthetized cats. Neuropharmacology, 32 (2): 185-193, 1993.

    Ally A., and Hara Y.: Blood pressure response to physostigmine: A species difference among rats, rabbits and cats. Journal of Bangladesh College of Physicians and Surgeons, 11(1): 6-10, 1993.

    Ally A., Meinjtes A.F., Mitchell J.H., and Wilson L.B.: Central cholinergic modulation of the exercise pressor reflex in anesthetized cats. American Journal of Physiology: Heart and Circulatory Physiology, 267(36): H109-H117, 1994.

    Ally A., Meinjtes A.F., Mitchell J.H., and Wilson L.B.: Effect of clonidine on the reflex cardiovascular responses and release of substance P during muscle contraction. Circulation Research, 75: 567-575, 1994.

    Ally A., Wilson L.B, Nóbrega A.C.L., and Mitchell J.H.: Cardiovascular effect of intracerebroventricular administration of physostigmine via M2 muscarinic receptors in conscious cats. Brain Research, 677(2): 268-276, 1995.

    Hand G.A., Meintjes A.F., Keister A.W., Ally A., and Wilson L.B.: NMDA receptor blockade in cat dorsal horn blunts the reflex pressor response to muscle contraction and stretch. American Journal of Physiology: Heart and Circulatory Physiology, 39: H500-H508, 1996.

    Ally A., Hand G.A., and Mitchell J.H.: Cardiovascular responses to static exercise in conscious cats: Effects of intracerebroventricular administration of clonidine. Journal of Physiology (London), 491(2): 519-527, 1996.

    Ishide T., Akasaka T., and Ally A.: Medical education and management of cardiovascular diseases in New England, The United States of America. Chiba Medical Journal, 73(42): 97-100, 1997.

    Ally A., Hand, G.A., and Mitchell J.H.: Central injection of physostigmine attenuates exercise-induced pressor response in conscious cats. American Journal of Physiology: Regulatory Integrative and Comparative Physiology, 273: R393-R399, 1997.

    Ally A., Caringi D., Koester D.J., Kobayashi T., and Mokler D.J.: Central 5-HT1A modulation of cardiovascular responses to tibial nerve stimulation-evoked muscle contraction. American Journal of Physiology 272: Regulatory, Integrative and Comparative Physiology, R1020-R1027, 1997.

    Hara Y., Nakaya H., Ally A., and Kondo H.: Effects of central nervous stimulants on spino-bulbo-spinal reflex potentials in cats. Journal of Veterinary Medical Science, 59(10): 911-915, 1997.

    Ally A.: Cardiovascular effects of central administration of clonidine in conscious cats. Brain Research, 761:283-289, 1997.

    Kobayashi T., Caringi D., Mokler D.J., and Ally A.: Effects of ventrolateral medullary AMPA receptor antagonism on the pressor response to muscle contraction. American Journal of Physiology: Heart and Circulatory Physiology, 272(41): H2774-H2781, 1997.

    Asmundsson G., Caringi D.C., Mokler D.J., Kobayashi T., Ishide T., and Ally A.: Extracellular serotonin changes in VLM during muscle contraction: effects of 5-HT1A receptor activation. American Journal of Physiology: Heart and Circulatory Physiology (Special Communication), 273(42): H2899-H2909, 1997.

    Caringi D.C., Mokler D.J., Koester D., and Ally A.: Rostral ventrolateral medullary opioid receptor activation modulates pressor response to muscle contraction. American Journal of Physiology: Heart and Circulatory Physiology, 274(43): H139-H146, 1998.

    Asmundsson G., Mokler, D.J., and Ally A.: Effects of ventrolateral medullary NMDA-receptor antagonism on biogenic amines and pressor response to muscle contraction. Neuroscience Research, 32: 47-56, 1998.

    Caringi D.C., Maher T.J., Chaiyakul P., Asmundsson G., Ishide T., and Ally A.: Extracellular glutamate increases in rostral ventrolateral medulla during static muscle contraction. Pflügers Archives of European Journal of Physiology, 435: 465-471, 1998

    Ally A.: Cardiovascular effects of intravenous administration of clonidine in conscious cats. Brain Research, 810(1-2): 153-160, 1998.

    Willard F.H., Carreiro J.E., Bates B., and Ally A.: The Osteopathic Medical Curriculum: Education of Medical students at the University of New England. Chiba Medical Journal, 74(6): 509-516, 1998.

    27Freda B.J., Gaitonde R.S., Lillaney R., and Ally A.: Cardiovascular responses to muscle contraction following microdialysis of nitric oxide precursor into ventrolateral medulla. Brain Research, 828:60-67, 1999.

    Lillaney R., Maher T.J., Chaiyakul P., and Ally A.: Changes in extracellular glutamate and pressor response during muscle contraction following AMPA-receptor blockade in the RVLM and CVLM. Brain Research, 844:164-173, 1999.

     Reidman D., Maher T.J., Chaiyakul P., and Ally A.: Modulation of extracellular glutamate and pressor response to muscle contraction during NMDA-receptor blockade in the rostral ventrolateral medulla. Neuroscience Research, 36: 147-156, 2000.

    Ishide T., Mancini M., Maher T.J., Chaiyakul P., and Ally A.: RVLM-opioid receptor activation modulates glutamate release and attenuates the exercise pressor reflex. Brain Research, 805: 177-185, 2000.

    Ishide T., Hara Y, Maher T.J., and Ally A.: Glutamate neurotransmission and nitric oxide interaction within the ventrolateral medulla during cardiovascular responses to muscle contraction. Brain Research, 874: 107-115, 2000.

    Chaiyakul P., Reidman D, Pilipovic L., Maher, T.J., and Ally A: Further evidence that extracellular serotonin in the rostral ventrolateral medulla modulates 5-HT1A receptor-mediated attenuation of exercise pressor reflex. Brain Research, 900: 186-194, 2001.

    Gray T., Lewis III E., Maher T.J., and Ally A.: AMPA-receptor blockade within the RVLM modulates cardiovascular responses via glutamate during peripheral stimuli. Pharmacological Research, 43: 47-54, 2001.

    Nauli S.M., Ally A., Zhang L., Gerthoffer W.T., and Pearce W.J.: Maturation attenuates the effects of cGMP on contraction, [Ca2+]i and Ca2+ sensitivity in ovine basilar arteries. General Pharmacology, 35(2): 107-118, 2001.

    Ishide T., Maher T.J., Nauli S.M., Pearce W.J., and Ally A.: Modulation of pressor response to muscle contraction via monoamines following AMPA-receptor blockade in the ventrolateral medulla.  Pharmacological Research, 44(6): 481-489, 2001.

    Nauli S.M., Pearce W.J., Amer A., Maher T.J., and Ally A.:  Effects of nitric oxide and GABA interaction within ventrolateral medulla on cardiovascular responses during static muscle contraction. Brain Research, 922(2): 234-242.2001.

    Ishide T., Maher T.J., Pearce W.J., Nauli S.M., Chaiyakul P., and Ally A.: Simultaneous glutamate and GABA release within ventrolateral medulla during muscle contraction in intact and barodenervated rats. Brain Research, 923(1-2): 137-146, 2001.

    Nauli S.M., Maher T.J., Pearce W.J., and Ally A.:  Effects of opioid receptor activation on cardiovascular responses and extracellular monoamines within the rostral ventrolateral medulla during static muscle contraction.   Neuroscience Research, 41(4): 373-383, 2001.

    Ishide T., Pearce, W.J., and Ally A.: Cardiovascular responses during stimulation of hindlimb skeletal muscle nerves in anesthetized rats. Clinical and Experimental Pharmacology and Physiology, 29 (8), 689-695, 2002.

    Ally A., Nauli S.M. and Maher T.J.: Cardiovascular responses and neurotransmission in the ventrolateral medulla during skeletal muscle contraction following transient middle cerebral artery occlusion and reperfusion. Brain Research, 952 (2): 176-187, 2002.

    Ishide T., Maher T.J., and Ally A: Role of nitric oxide in the ventrolateral medulla on cardiovascular responses and glutamate neurotransmission during mechanical and thermal nociception. Pharmacological Research, 47(1): 59-68, 2003.

    Ishide T., Nauli S.M., Maher T.J. and Ally A.: Cardiovascular responses and neurotransmitter changes following blockade of nNOS within the ventrolateral medulla during static muscle contraction. Brain Research, 977(1): 80-9, 2003.

    Ally A. and Maher T.J.: Interaction among the three isoforms of nitric oxide synthase and the exercise pressor reflex. The Physiologist, 47(4), 279, 2004.

    Ishide T., Amer A., Maher T.J. and Ally A.: Role of nitric oxide in the periaqueductal grey on cardiovascular responses and extracellular glutamate concentrations during mechanical and thermal nociception. Neuroscience Research, 51(1): 93-103, 2004.

    Ishide T., Preuss C.V., Maher T.J. and Ally A.: Neurochemistry within ventrolateral medulla and cardiovascular effects during static exercise following eNOS antagonism. Neuroscience Research, 52 (1): 21-30, 2005.

    Ally A., Nauli, S.M., and Maher T.J.: Molecular changes in nNOS protein expression within the ventrolateral medulla following transient focal ischemia affect cardiovascular functions. Brain Research, 1055(1-2):73-82, 2005.

    Ally A., Phattanarudee S., Kabadi S., Patel M., and Maher T.J.: Cardiovascular responses and neurotransmitter changes during static muscle contraction following blockade of inducible nitric oxide synthase (iNOS) within the ventrolateral medulla. Brain Research, 1090(1):123-33, 2006.

    Karlsson G.A., Preuss C.V., Chaitoff K.A., Maher T.J., and Ally A.: Medullary monoamines and NMDA receptor regulation of cardiovascular responses during peripheral nociceptive stimuli.  Neuroscience Research, 55(3):316-326, 2006.

    Karlsson, G.A., Chaitoff K.A., Hossain S., Böhlke M., Maher T.J., and Ally A.: Modulation of cardiovascular responses and neurotransmission during peripheral nociception following nNOS antagonism within the periaqueductal gray.  Brain Research, 1143: 150-160, 2007.

    Ally A., Phattanarudee S., Kabadi S., Patel M., and Maher T.J.: Neuronal nitric oxide synthase (nNOS) blockade within the ventrolateral medulla differentially modulates cardiovascular responses and nNOS expression during static skeletal muscle contraction. Brain Research, 1150: 21-31, 2007.

    Ally A. and Maher T.J.: Endothelial NOS expression within the ventrolateral medulla can affect cardiovascular functions in stroked rats. Brain Research, 1196: 33-40, 2008.

    Patel D., Böhlke M., Phattanarudee S., Kabadi S., Maher T.J., and Ally A.: Cardiovascular responses and neurotransmitter changes during blockade of angiotensin II receptors within the ventrolateral medulla. Neuroscience Research, 60(3): 340-348, 2008.

    Kabadi S., and Ally A.: Negative cardiotropism by catestatin and its variants. Endocrinology, 149(10): 4778-4779, 2008.

    Chaitoff K.A., Patel D. and Ally A.: Effects of endothelial NOS antagonism within the periaqueductal gray on cardiovascular responses and neurotransmission during mechanical, heat, and cold nociception.  Brain Research, 1236: 93-104, 2008.

    Tedesco, A. and Ally A.: Blockade of angiotensin II (Type II) receptors within the ventrolateral medulla differentially modulates cardiovascular responses during static exercise. Neuroscience Research, 64(4): 372-379, 2009.

    Ally A. and Maher T: Inducible NOS expression within the ventrolateral medulla affecting cardiovascular functions in stroked rats. Canadian Journal of Physiology and Pharmacology, 89(9):639-46, 2011.

    Chaitoff K.A., Tedesco, A., Toner, F., Maher, T, and Ally A.: Cardiovascular responses following blockade of iNOS within the periaqueductal grey during mechanical, heat and cold nociception. Neurological Sciences, Feb; 33(1): 69-78, 2012.

    Phattanarudee S., Towiwat, P., Maher, T.J., and Ally, A.: Effects of medullary administration of a nitric oxide precursor on cardiovascular responses and neurotransmission during static exercise following ischemic stroke. Canadian Journal of Physiology and Pharmacology, July; 91(7): 510-520, 2013.

    Phattanarudee S., Towiwat, P., Maher, T.J., and Ally, A.: Effects of medullary administration of a nitric oxide precursor on cardiovascular responses and neurotransmission during static exercise following ischemic stroke. Canadian Journal of Physiology and Pharmacology, July; 91(7): 510-520, 2013.

    Towiwat P, Phattanarudee S, Maher, T.J., and Ally, A.: Modulation of cardiovascular activity and inducible NOS expression following iNOS antagonism within the ventrolateral medulla during static exercise. Molecular and Cellular Biochemistry, 398(1-2):185-194, 2014.

    Ally, A. and Chaitoff, K.C.: Toxicology of drugs used in the treatment of peripheral neuropathy. Toxicology - Past, Present and Future of Basic, Clinical, and Forensic Medicine, 1: Volume 2: 2015.

    REVIEWS
    Ally A.: Ventrolateral medullary control of cardiovascular activity during muscle contraction.  Neuroscience and Biobehavioral Reviews, 23(1): 65-86, 1998.

    Ishide T. and Ally A.: The role of β1-receptor selective agonist in long-term control of chronic heart failure. Respiration and Circulation, 48(4): 375-381, 2000.

    Kabadi S., Maher T.J., and Ally A.: Neuronal Nitric Oxide Synthase (NOSI). BioMed Central, Ubiquitin Proteasome System (UPS), 2009.

    MANUSCRIPT IN PREPARATION
    Ally, A. and Maher, T.J.: Effects of endothelial NOS antagonism on eNOS expression and cardiovascular activity during static muscle contractions. Brain Research, 2012

    Ally A.: Effects of AMPA-Glutamate receptors blockade in the lateral reticular nucleus on the cardiovascular responses to static muscle contraction in anesthetized rats. American Journal of Physiology (Heart and Circulatory Physiology).

    Ally, A., Phattanarudee, S., Shafique, E., Maher, T.J. Effects of medullary administration of nitric oxide precursor on cardiovascular responses and nNOS protein during static exercise in stroke rats. Neurological Sciences.

    Ally, A., Maher, T.J. Effects of medullary administration of nitric oxide precursor on cardiovascular responses and eNOS protein during static exercise in stroke rats. Neurological Sciences.

    Ally, A., Maher, T.J. Effects of medullary administration of nitric oxide precursor on cardiovascular responses and iNOS protein during static exercise in stroke rats. Neurological Sciences.

    Ally A.: Cardiovascular responses and neurotransmitter changes to static muscle contraction following nNOS antagonism within the ventrolateral medulla in rats with transient middle cerebral artery occlusion and reperfusion. Brain Research

    Ally A.: Changes in nNOS expression and evaluation of cardiovascular responses to muscle contraction after nNOS antagonism within the ventrolateral medulla in stroke rats. Brain Research

    Ally A.: Cardiovascular responses and neurotransmitter changes to static muscle contraction following eNOS antagonism within the ventrolateral medulla in rats with transient middle cerebral artery occlusion and reperfusion. Brain Research

    Ally A.: Changes in eNOS expression and evaluation of cardiovascular responses to muscle contraction after eNOS antagonism within the ventrolateral medulla in stroke rats. Brain Research

    Ally A. and Maher T.J.: Cardiovascular responses and neurotransmitter changes to static muscle contraction following iNOS antagonism within the ventrolateral medulla in rats with transient middle cerebral artery occlusion and reperfusion. Brain Research

    Ally A. and Maher T.J.: Changes in iNOS expression and evaluation of cardiovascular responses to muscle contraction after iNOS antagonism within the ventrolateral medulla in stroke rats. Brain Research

  • Activities

    2004- American Heart Association: Integrative Cardiac Biology Regulation, Vascular Biology, and Blood Pressure Regulation, Cardio-renal Physiology.

    2007- Alzheimer’s Disease Research Center Pilot Grant Program, University of Alabama, Birmingham, AL

    Previously: From 1994 to 2015

    Chair, School of Pharmacy Research Committee

    Chair, Faculty Development and Affairs Committee

    Member, Graduate Curriculum Committee

    Member, Strategic Planning Committee

    Academic Standing and Progression Committee

    Member, Institutional Animal Use and Care Committee

    Member, School of Pharmacy Attendance Policy Task Force

    Member, Pharmaceutical Sciences Faculty Search Committee

    Member, Admissions and Assessment Committee

    Member, Research Committee

    Member, Curriculum Committee

  • News

     

Education & Training

  • PhD: Chiba University School of Medicine, Japan 1992
  • Fellowship Cardiology, Moss Heart Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
  • Medical Residency Internal Medicine Dhaka Medical College and Hospital 1987
  • MD: Dhaka Medical College, Bangladesh 1983

Departments & Committees

  • Pharmacology
  • Physiology
  • Introduction to Clinical Medicine
  • Examination Committee
  • Curriculum Committee
  • Research Committee