Dr. Podcheko is an Endocrinologist with over a decade of experience in active Medical research, Medical education and Academic administration.
He leads the Basic Sciences program at AUIS with a focus on personal development of each student through critical thinking skills, active teaching and effective mentoring. As an educator he believes in producing real-world health professionals with an acute sense of fiscal and social accountability. His father, Dr. Peter Podcheko, an actively practising physician, has been his mentor and taught him the 3 tenets of good teaching: patience, respect for students and expertise in his speciality. He is an accomplished professor of Pathological Sciences with interest in curriculum development, valuation, faculty recruitment and appointment, and student progress and promotion.
Main area of Dr. Podcheko research interests and expertise is Molecular Endocrinology. His work has focused on elucidation of mechanisms of thyroid carcinogenesis for development of treatment strategies; and describing molecular mechanisms involved in the protection of insulin producing beta cells of the pancreas from diabetogenic insults.
His most recent publication includes,"Pharmacological Inhibition of Intracellular Signaling Pathways in Radioresistant Anaplastic Thyroid Cancer" published in 2016 in the book "New Aspects in Molecular and Cellular Mechanisms of Human Carcinogenesis" and "Calreticulin and focal contact-dependent adhesion" published in Biochemistry and Cell Biology Journal, 2009. Other research contributions from Dr. Podcheko incorporate his research to improve understanding of survival and proliferative mechanisms in insulin producing islet beta-cells which triggered a series of research targeted to identify the role of PHIP1 as potential antidiabetic target therapy.
Dr. Podcheko was an invited speaker on the topic of “Gleevec radio- sensitizes anaplastic cancer cells” at the First Nagasaki Symposium of International Consortium for Medical Care of Hibakusha and Radiation Life Science, Nagasaki, Japan speaker at Banting and Best Diabetes Centre, University of Toronto 20th Annual Scientific Day on the topic of Control of Beta cell function by PHIP: Implications for Type I and II Diabetes.
2013 - NO-dependent pathway of the adaptation to ischemic damage of lower limb tissue under an experimental injection of mesenchymal stem cells. Second mini symposium "Stem cell day". Kyiv. Uk
2014 - Dynamics of changes in a content of free nitric oxide metabolites in kidney tissue in the transient acute renal ischemia under experimental conditions. All-Ukrainian scientific and practical conference with international participation "Aspects of pharmaceutical and medical research at the present stage", Lugansk, Uk
2016 - Content of adenyl nucleotides in a culture of rat mesenchymal stem cells. International scientific conference of the young scientists in medicine, Kursk-Voronezh-Kazan, Russia
Novikov VI, Molotkov OV, Podcheko AP, Babichev AV. The effect of thymic peptides on the development of streptozotocin-induced diabetes mellitus. Patol Fiziol Eksp Ter. 1999 Jul-Sep;(3):25-8.Podtcheko A, Ohtsuru A, Tsuda S, Namba H, Saenko V, Nakashima M, Mitsutake N, Kanda S, Kurebayashi J, Yamashita S. The selective tyrosine kinase inhibitor, STI571, inhibits growth of anaplastic thyroid cancer cells. J Clin Endocrinol Metab. 2003 Apr;88(4): 1889-96
Podtcheko A, Ohtsuru A, Namba H, Yamashita S. Authors' Response: Effect of Imatinib Mesylate (Gleevec) on Anaplastic Thyroid Carcinoma Cell Lines. J Clin Endocrinol Metab. 2003 Oct;88(10):5043-4; author reply 5044. doi: 10.1210/jc.2003-031269 Alexei Podtcheko, Hiroyuki Namba, Vladimir Saenko, Akira Ohtsuru, Dmitriy Starenki, Serik Meirmanov, Iryna Polona, Tatiana Rogounovitch and Shunichi Yamashita. Radiation-induced Senescence-like Terminal Growth Arrest in Thyroid Cells. Thyroid. 2005 Apr;15(4):306-13. Alexei Podtcheko, Akira Ohtsuru, Hiroyuki Namba, Vladimir Saenko, Dmitriy Starenki, Serik Meirmanov, Iryna Polona, Tatiana Rogounovitch and Shunichi Yamashita. Inhibition of c-ABL Tyrosine Kinase Potentiates Radiation-InducedTerminal Growth Arrest in Anaplastic Thyroid Cancer Cells. Radiation Research, 194, 2005
Bulgin D, Podtcheko A, Takakura S, Mitsutake N, Namba H, Saenko V, Ohtsuru A, Rogounovitch T, Palona I, Yamashita S. Selective pharmacologic inhibition of c-Jun NH2-terminal kinase radiosensitizes thyroid anaplastic cancer cell lines via induction of terminal growth arrest. Thyroid. 2006 Mar;16(3):217-24.5
Palona I, Namba H, Mitsutake N, Starenki D, Podtcheko A, Sedliarou I, Ohtsuru A, Saenko V, Nagayama Y, Umezawa K and Yamashita S. BRAFV600E Promotes Invasiveness of Thyroid Cancer Cells through NF-κB Activation. Endocrinology. 2006
A Podcheko, P Northcott, G Bikopoulos, A Lee, B Swaroop, J Kushner, J Farhang-Fallah, M Rozakis-Adcock. IDENTIFICATION OF A WD-40 REPEAT-CONTAINING ISOFORM OF PHIP AS A NOVEL REGULATOR OF BETA-CELL GROWTH AND SURVIVAL. Molecular and Cellular Biology, September 2007, p. 6484-6496, Vol. 27, No. 18.
Lee A, Podcheko A, Hakuno F, Northcott P, Huang X, Schibli D, Li SC, Pessin JE and Rozakis-Adcock M. 2007) Identification of novel cytoskeletal protein that binds and regulates IRS 1 signalling in muscle cells. Maria Villagomez, Eva Szabo, Alexey Podcheko, Tianshu Feng, Sylvia Papp and Michal Opas. Calreticulin and focal contact-dependent adhesion; Biochemistry and Cell Biology Aug 2009