Professor of Biochemistry and Genetics

Dr. Bao received his Ph.D. in Molecular Biophysics from Chinese Academy of Sciences, Beijing, China in 1996. His Ph.D. research was focused on structural analyses of the key metabolic hormone insulin and an enzyme fructose-2,6-bisphosphatase. This work led to a publication in P.N.A.S. (Bao et al, 1997: Proc. Natl. Acad. Sci. U.S.A. 94, 2975-2980). Shortly after receiving his Ph.D., he became an Assistant Professor in the Institute of Biophysics, Chinese Academy of Sciences. In 1999, he was awarded Guest Scientist Scholarship by German Cancer Research Center (DFKZ), Heidelberg, Germany, to work on the signal transduction pathway mediated by the oncoprotein Wnt. In 2001, he moved to the United States and worked as a post-doctoral fellow in the Department of Molecular Biology and Pharmacology at Washington University School of Medicine in St. Louis where he studied molecular and cell biology with a focus on cell-cell adhesion and control of gene expression (Bao et al, 2005: Developmental Cell 8, 925-935).  He continued this work at Mount Sinai School of Medicine, New York (Bao et al, 2010: Developmental Biology 344, 948-956). In 2009, he became an Assistant Professor in the Department of Pediatrics at Mount Sinai School of Medicine where he studied microbiology with a focus on engineering bacteria to deliver therapeutic agents (Bao et al, 2013: PLoS One 8, e60007). In 2012, he became an Associate Professor at Saint James School of Medicine and was promoted to Full Professor in 2017. He joined the faculty of American University of Integrative Sciences in 2019 as Professor of Biochemistry and Genetics. Through affiliation with several medical schools, he has established a diverse teaching portfolio and taught multiple subjects including biochemistry, genetics, cell biology, physiology, microbiology, and immunology. His teaching philosophy features simplicity and knowledge integration.

Previous Positions

Professor, Saint James School of Medicine (St. Vincent) Courses taught: Biochemistry and Genetics; Physiology

Assistant Professor, Mount Sinai School of Medicine, New York, USA

Postdoctoral Fellow, Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, USA

Guest Scientist, German Cancer Research Center (DKFZ), Heidelberg, Germany Research: signal transduction by the Wnt signaling pathway; Role: Guest Scientist Support: Guest Scientist Scholarship, German Cancer Research Center, Heidelberg, Germany

Research Interests

Use of bacteriophages to treat bacterial infections

Presentations

Finalist, O’Leary Prize, Washington University School of Medicine, St. Louis, 2006; Invited speaker, by Indiana University and 14 other institutions in the U.S. and Germany

Speaker  University of Freiburg, Germany, 2013: “Two counteracting mechanisms in determination of unique cell shapes”  University of Miami, Miller School of Medicine , 2009: “Cell adhesion and organ assembly” University of Cologne, Germany, 2009: “Cell adhesion and organ assembly”  12th European Drosophila Neurobiology Conference, University of Würzburg, Germany, 2008: “Cell adhesion, cell signaling and hexagons in the Drosophila eye” New York Academy of Sciences, New York, 2008: “Adhesion and signaling: patterning the pupal eye”  Department of Biology, Indiana University, Bloomington, 2007: “Pattern formation in the Drosophila eye” Department of Biology, Hunter College, New York, 2007: “Cell adhesion: more than sticky business” Department of Biology, Manhattan College, New York, 2007: “Pattern formation in the Drosophila eye”  46th Annual Midwest Developmental Biology Meeting, Chicago, 2007 : “Notch is required for organizing cells into a unique pattern in the Drosophila eye” Southeast Regional Society of Developmental Biology Meeting, Vanderbilt University, Nashville, 2006: “Regulation of cell recognition and cell movements by Hibris and Roughest in the Drosophila eye”  46th Annual Drosophila Research Conference, San Diego, 2005: “Cell Adhesion mediated by Hibris and Roughest Regulates Morphogenesis in the Drosophila Eye” Inaugural Postdoctoral Scientific Symposium, Washington University, St. Louis, 2005: “Cell Adhesion mediated by Hibris and Roughest Regulates Morphogenesis in the Drosophila Eye” Midwest Drosophila Conference, Allerton, 2004: “Interactions Between the Hibris and IrreC-Rst Regulate Morphogenesis in the Developing Drosophila Eye”  Asian Academy Seminar on Supramolecular Organization in Chemistry, Material Science, and Biology, Bangalore, India, 1997: “Crystal structure of desheptapeptide(B24-B30) insulin and biological implications”

Publications

1. Hang H, Zhao L, Bian C, Dong J, Dai Y, Bao S, Xu J, Xia G and Xu L (2018). Oxygen is required to maintain mitochondrial integrity in preserved livers. Journal of Hepatology (submitted). 2. Jie Ni, Sujin Bao, Ruth I Johnson Bingbing Zhu et al (2016). MAGI-1 Interacts with Nephrin to Maintain Slit Diaphragm Structure Through Enhanced Rap1 Activation in Podocytes. Journal of Biological Chemistry 291, 24406-24417. 3. Bian C, Du Y, Ding R, Huang J, Dai Y, Bao S, Zhao L, Shen H, Dong J, Xu J, Xiong Q & Xu L. (2016). Biliary epithelial cells proliferate during oxygenated ex-situ liver culture. American Journal of Translational Research 8, 3955-3962. 4. Dong J, Xia L, Shen H, Bian C, Bao S, Zhang M, Du Y, Dai Y, Zhao L, Xu Y, Xiong Q, Xu J & Xu L. (2016). Growing a whole porcine liver organ ex-situ for six hours without red blood cells or hemoglobin. American Journal of Translational Research 8, 2562-74. 5. Sujin Bao*, (2014). Cell adhesion in the assembly of the Drosophila eye. Journal of Neurogenetics 28, 282- 290. 6. Sujin Bao* (2014). Notch controls cell adhesion in the Drosophila eye. PLOS Genetics 10: e1004087. 7. Sujin Bao*, Qiang Zhuang, Libin Zhu, Lucia Wang, Ian Holzman, Pin-xian Xu and Jing Lin (2013). Localization dynamics of lactobacilli in the gastrointestinal tract of neonatal rats. PLoS One 8, e60007. 8. Ruth I. Johnson, Sujin Bao and Ross L. Cagan (2012). Interactions between Drosophila IgCAM adhesion receptors and Cindr, the Cd2ap/Cin85 ortholog. Developmental Dynamics 241, 1933-43. 9. Sujin Bao* (2010). Two themes on the assembly of the Drosophila eye. Current Topics in Developmental Biology 93, 83-125. 10. Sujin Bao*, Karl-Friedrich Fischbach, Vicki Corbin and Ross Cagan (2010). Preferential adhesion maintains separation of ommatidia in the Drosophila eye. Developmental biology 344, 948-956. 11. Miroslawa Siatecka, Felix Lohmann, Sujin Bao, and James J. Bieker (2010). EKLF directly activates the p21WAF1/CIP1 gene by proximal promoter and novel intronic regulatory regions during erythroid differentiation. Molecular and Cellular Biology 30, 2811-2822. 12. Midori J. Seppa, Ruth I. Johnson, Sujin Bao and Ross Cagan (2008). Polychaetoid controls patterning by modulating adhesion in the Drosophila pupal retina. Developmental Biology 314, 1-16. 13. Sujin Bao* and Ross Cagan (2006). Fast cloning inverted repeats for RNA interference. RNA 12, 2020-2024. 14. Sujin Bao and Ross Cagan (2005). Preferential adhesion mediated by Hibris and Roughest regulates morphogenesis and patterning in the Drosophila eye. Developmental Cell 8, 925-935. 15. Julia Cordero, Omar Jassim, Sujin Bao & Ross Cagan (2004). A role for wingless in an early pupal cell death event that contributes to patterning the Drosophila eye. Mechanism of Development 121, 1523-30. 16. Sujin Bao and Ross Cagan (2003). Cell death in Drosophila. In Essentials of apoptosis: A Guide for Basic and Clinical Research (eds. Yin, X.M. and Dong. Z.), pp145-161, Humana Press Inc., Totowa, NJ. 17. Bao Sujin, Zhang Jiping, Chang Wenrui & Liang Dongcai (1999). Structure of desheptapeptide(B24-B30) insulin in a new crystal form. Science in China C42, 267-273. 18. Bao Sujin, Xie Dianlin, Zhang Jiping, Chang Wenrui & Liang Dongcai (1998). Structural analysis of desheptapeptide(B24-B30) insulin by molecular replacement. Science in China C41, 258-264. 4 19. Su-jin Bao, Dian-lin Xie, Ji-ping Zhang, Wen-rui Chang and Dong-cai Liang (1997). Crystal structure of desheptapeptide(B24-B30) insulin at 1.6Å resolution: implications for receptor binding. Proceedings of the National Academy of Sciences U.S.A 94, 2975-2980. 20. Bao Sujin, Wan Zhuli, Chang Wenrui, Gui lulu, Liang Dongcai etal. (1996). Preliminary crystallographic analysis of recombinant chicken liver fructose-2, 6-bisphosphatase. Science in China B39, 7-10. 21. Shu-ye Lei, Su-jin Bao and Bu-xuan Wang (1992). A model for heat and mass transfer in unsaturated wet porous media with infiltration. In Transport Phenomena Science and Technology (Wang, B.X., ed.), pp.639- 644, Higher Education Press, Beijing. 22. Shu-ye Lei, Su-jin Bao, Wei-cheng Wang and Bu-xuan Wang (1992). Measurement of porosity and permeability of unconsolidated porous media. Journal of Engineering Thermophysics 13, 408-411.

Education

1992-1996 Ph.D. in Molecular Biophysics: Institute of Biophysics, Chinese Academy of Sciences (CAS), Beijing, China Thesis: Determination of crystal structure of desheptapeptide (B24-B30) insulin and preliminary crystallographic analysis of Fructose 2,6-bisphophatase

1989-1992 M.Sc. in Thermophysics Engineering: Tsinghua University, Beijing, China Thesis: Physico-mathematical model of heat and mass transfer in unsaturated wet porous media

1985-1989 B.Sc. in Engineering: Dalian University of Technology, Dalian, China

Departments & Committees

Department:

  • Molecular and Cell Biology

Committees:

  • Curriculum Committee
  • Research Committee (Chair)
  • Examination Committee
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